2. Metabolic Disease

Metabolic Disease

Metabolic Disease

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Metabolic diseases is defined by a constellation of interconnected physiological, biochemical, clinical, and metabolic factors that directly increases the risk of cardiovascular disease, type 2 diabetes mellitus, and all cause mortality. Associated conditions include hyperuricemia, fatty liver (especially in concurrent obesity) progressing to nonalcoholic fatty liver disease, polycystic ovarian syndrome (in women), erectile dysfunction (in men), and acanthosis nigricans. Metabolic disease modeling is an essential component of biomedical research and a mandatory prerequisite for the treatment of human disease. Somatic genome editing using CRISPR/Cas9 might be used to establish novel metabolic disease models.

Cat. No. Product Name CAS No. Purity Chemical Structure
  • HY-Y1009S
    Methoxyacetic acid-d3 345910-00-1 98%
    Methoxyacetic acid-d3 is the deuterium labeled Methoxyacetic acid (HY-Y1009). Methoxyacetic acid is a metabolite of ethylene glycol monomethyl ether. When the concentration of methoxyacetic acid reaches a certain level, it can inhibit the respiratory function of hepatic mitochondria and testicular mitochondria. Methoxyacetic acid is somewhat toxic.
    Methoxyacetic acid-d3
  • HY-Y1031R
    3-Ethoxy-3-oxopropanoic acid (Standard) 1071-46-1
    3-Ethoxy-3-oxopropanoic acid (Standard) is the analytical standard of 3-Ethoxy-3-oxopropanoic acid. This product is intended for research and analytical applications. 3-Ethoxy-3-oxopropanoic acid is an endogenous metabolite. 3-Ethoxy-3-oxopropanoic acid promotes plant growth[1].
    3-Ethoxy-3-oxopropanoic acid (Standard)
  • HY-Y1139R
    Pimelic acid (Standard) 111-16-0
    Pimelic acid (Standard) is the analytical standard of Pimelic acid. This product is intended for research and analytical applications. Pimelic acid is the organic compound and its derivatives are involved in the biosynthesis of the amino acid called lysine.Pimelic acid can be used in keratoconus research.
    Pimelic acid (Standard)
  • HY-Y1139S
    Pimelic acid-d4 19031-56-2 98%
    Pimelic acid-d4 is the deuterium labeled Pimelic acid. Pimelic acid is the organic compound and its derivatives are involved in the biosynthesis of the amino acid called lysine.
    Pimelic acid-d4
  • HY-Y1297R
    Oxalic acid dihydrate (Standard) 6153-56-6
    Oxalic acid dihydrate (Standard) is the analytical standard of Oxalic acid dihydrate. This product is intended for research and analytical applications. Oxalic acid dihydrate is an endogenous metabolite.
    Oxalic acid dihydrate (Standard)
  • HY-Y1298R
    Methyl acetylacetate (Standard) 105-45-3
    Methyl acetylacetate (Standard) is the analytical standard of Methyl acetylacetate. This product is intended for research and analytical applications. Methyl acetylacetate is an endogenous metabolite.
    Methyl acetylacetate (Standard)
  • HY-Y1314S
    Dimethyl sulfone-d6 22230-82-6 98%
    Dimethyl sulfone-d6 is the deuterium labeled Dimethyl sulfone. Dimethyl sulfone is an endogenous metabolite.
    Dimethyl sulfone-d6
  • HY-Y1422B
    Lipase (MS grade) 9001-62-1
    Lipase (MS grade) catalyzes the hydrolysis of triacylglycerols to release long-chain fatty acids in a site-specific manner. Lipase (MS grade) is involved in a variety of biological processes, from fat metabolism to cell signaling and inflammation, and can be used to treat diseases such as pancreatic insufficiency, celiac disease and cystic fibrosis.
    Lipase (MS grade)
  • HY-Y1636S
    Fmoc-Arg(Pbf)-OH-13C6,15N4 1217461-89-6 98%
    Fmoc-Arg(Pbf)-OH-13C6,15N4 is the 13C-labeled and 15N-labeled Fmoc-Arg(Pbf)-OH (HY-Y1636). Fmoc-Arg(Pbf)-OH is an arginine derivative containing amine protecting group Fmoc. Fmoc-Arg(Pbf)-OH is a building block for the introduction of Arg into SPPS (Solid-Phase Peptide Synthesis).
    Fmoc-Arg(Pbf)-OH-13C6,15N4
  • HY-Y1644R
    (E)-Crotonic acid (Standard) 107-93-7
    (E)-Crotonic acid (Standard) is the analytical standard of (E)-Crotonic acid. This product is intended for research and analytical applications. (E)-Crotonic acid is an endogenous metabolite.
    (E)-Crotonic acid (Standard)
  • HY-Y1644S
    3,3-Dimethylacrylic acid-d6 21386-86-7 98%
    3,3-Dimethylacrylic acid-d6 is the deuterium labeled 3,3-Dimethylacrylic acid . 3,3-Dimethylacrylic acid-d6 is an endogenous metabolite.
    3,3-Dimethylacrylic acid-d6
  • HY-Y1667S
    2,6-Dibromophenol-d3 1219803-14-1 98%
    2,6-Dibromophenol-d3 is the deuterium labeled 2,6-Dibromophenol. 2,6-Dibromophenol is an endogenous metabolite.
    2,6-Dibromophenol-d3
  • HY-Y1750A
    β-Aminopropionitrile hydrochloride 646-03-7 98%
    β-Aminopropionitrile (BAPN) hydrochloride is a specific, irreversible and orally active lysyl oxidase (LOX) inhibitor. β-Aminopropionitrile hydrochloride targets the active site of LOX or LOXL isoenzymes.
    β-Aminopropionitrile hydrochloride
  • HY-Y1809R
    1-Hydroxyoctadecane (Standard) 112-92-5
    1-Hydroxyoctadecane (Standard) is the analytical standard of 1-Hydroxyoctadecane. This product is intended for research and analytical applications. 1-Hydroxyoctadecane is an endogenous metabolite.
    1-Hydroxyoctadecane (Standard)
  • HY-Y1809S
    1-Hydroxyoctadecane-d37 204259-62-1 98%
    1-Hydroxyoctadecane-d37 is the deuterium labeled 1-Hydroxyoctadecane. 1-Hydroxyoctadecane is an endogenous metabolite.
    1-Hydroxyoctadecane-d37
  • HY-Z0031R
    (R)-(-)-1,2-Propanediol (Standard) 4254-14-2
    (R)-(-)-1,2-Propanediol (Standard) is the analytical standard of (R)-(-)-1,2-Propanediol. This product is intended for research and analytical applications. (R)-(-)-1,2-Propanediol is a (R)-enantiomer of 1,2-Propanediol that produced from glucose in Escherichia coli expressing NADH-linked glycerol dehydrogenase genes[1].
    (R)-(-)-1,2-Propanediol (Standard)
  • HY-Z12431
    Silodosin carboxylic acid impurity 1357252-79-9
    Silodosin carboxylic acid impurity (KMD-3293) is an inactive silodosin metabolite. Silodosin carboxylic acid impurity is the major metabolite that can be generated via oxidation by alcohol and aldehyde dehydrogenase. Silodosin carboxylic acid impurity can be studied in research for benign prostatic hyperplasia.
    Silodosin carboxylic acid impurity
  • HY-100171A
    PRX933 313658-33-2 98%
    PRX933 (GW876167) is a 5-HT2C agonist that can be used in the study of obesity and glaucoma.
    PRX933
  • HY-100587R
    D-Glutamine (Standard) 5959-95-5
    D-Glutamine (Standard) is the analytical standard of D-Glutamine. This product is intended for research and analytical applications. D-Glutamine is a cell-permeable D type stereoisomer of Glutamine.
    D-Glutamine (Standard)
  • HY-100596G
    AS1842856 (GMP) 836620-48-5
    AS1842856 (GMP) is AS1842856 (HY-100596) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. AS1842856, a specific Foxo1 inhibitor (IC50=30 nM), potently suppresses autophagy. AS1842856 reduces Foxo1 activity and, to a lesser extent, inhibits Foxo1 protein expression by simply binding to Foxo1.
    AS1842856 (GMP)
Cat. No. Product Name / Synonyms Application Reactivity